transcriptomics

Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity (Research Article)
Developmental trajectories of gene expression may reverse in their direction during ageing, a phenomenon previously linked to cellular …
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Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity (Research Article)
Convergent evolution of primate testis transcriptomes reflects mating strategy (Research Article)
In independent mammalian lineages where females mate with multiple males (multi-male mating strategies), males have evolved larger …
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Convergent evolution of primate testis transcriptomes reflects mating strategy (Research Article)
Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice (Research Article)
Genetically modified mouse models of ageing are the living proof that lifespan and healthspan can be lengthened or shortened, and …
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Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice (Research Article)
Transposable Element Landscape in Drosophila Populations Selected for Longevity (Research Article)
Transposable elements (TEs) inflict numerous negative effects on health and fitness as they replicate by integrating into new regions …
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Transposable Element Landscape in Drosophila Populations Selected for Longevity (Research Article)
Temporal changes in the gene expression heterogeneity during brain development and aging (Research Article)
Cells in largely non-mitotic tissues such as the brain are prone to stochastic (epi-)genetic alterations that may cause increased …
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Temporal changes in the gene expression heterogeneity during brain development and aging (Research Article)
Molecular footprint of Medawar’s mutation accumulation process in mammalian aging (Research Article)
Medawar’s mutation accumulation hypothesis explains aging by the declining force of natural selection with age: Slightly …
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The widespread increase in inter-individual variability of gene expression in the human brain with age (Research Article)
Aging is broadly defined as a time-dependent progressive decline in the functional and physiological integrity of organisms. Previous …
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Gene expression-based drug repurposing to target aging (Research Article)
Aging is the largest risk factor for a variety of noncommunicable diseases. Model organism studies have shown that genetic and chemical …
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Gene expression-based drug repurposing to target aging (Research Article)
Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity (Research Article)
It was previously reported that mRNA expression levels in the prefrontal cortex at old age start to resemble pre-adult levels. Such …
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Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity (Research Article)