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development vs ageing
Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity (Research Article)
Developmental trajectories of gene expression may reverse in their direction during ageing, a phenomenon previously linked to cellular …
Hamit İzgi
,
DingDing Han
,
Ulas Isildak
,
Shuyun Huang
,
Ece Kocabiyik
,
Philipp Khaitovich
,
Mehmet Somel
,
H. Melike Dönertaş
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DOI
Temporal changes in the gene expression heterogeneity during brain development and aging (Research Article)
Cells in largely non-mitotic tissues such as the brain are prone to stochastic (epi-)genetic alterations that may cause increased …
Ulas Isildak
,
Mehmet Somel
,
Janet M. Thornton
,
H. Melike Dönertaş
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DOI
Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity (Research Article)
It was previously reported that mRNA expression levels in the prefrontal cortex at old age start to resemble pre-adult levels. Such …
H. Melike Dönertaş
,
Hamit İzgi
,
Altuğ Kamacıoğlu
,
Zhisong He
,
Philipp Khaitovich
,
Mehmet Somel
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