ageing

Functional conservation in genes and pathways linking ageing and immunity (Review Article)
At first glance, longevity and immunity appear to be different traits that have not much in common except the fact that the immune …
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Functional conservation in genes and pathways linking ageing and immunity (Review Article)
Common genetic associations between age-related diseases (Research Article)
Age is a common risk factor in many diseases, but the molecular basis for this relationship is elusive. In this study we identified …
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Common genetic associations between age-related diseases (Research Article)
Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice (Research Article)
Genetically modified mouse models of ageing are the living proof that lifespan and healthspan can be lengthened or shortened, and …
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Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice (Research Article)
Transposable Element Landscape in Drosophila Populations Selected for Longevity (Research Article)
Transposable elements (TEs) inflict numerous negative effects on health and fitness as they replicate by integrating into new regions …
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Transposable Element Landscape in Drosophila Populations Selected for Longevity (Research Article)
Temporal changes in the gene expression heterogeneity during brain development and aging (Research Article)
Cells in largely non-mitotic tissues such as the brain are prone to stochastic (epi-)genetic alterations that may cause increased …
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Temporal changes in the gene expression heterogeneity during brain development and aging (Research Article)
Molecular footprint of Medawar’s mutation accumulation process in mammalian aging (Research Article)
Medawar’s mutation accumulation hypothesis explains aging by the declining force of natural selection with age: Slightly …
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The widespread increase in inter-individual variability of gene expression in the human brain with age (Research Article)
Aging is broadly defined as a time-dependent progressive decline in the functional and physiological integrity of organisms. Previous …
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Identifying Potential Ageing-Modulating Drugs In Silico (Review Article)
Increasing human life expectancy has posed increasing challenges for healthcare systems. As people age, they become more susceptible to …
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Identifying Potential Ageing-Modulating Drugs In Silico (Review Article)
Using the drug-protein interactome to identify anti-ageing compounds for humans (Research Article)
Advancing age is the dominant risk factor for most of the major killer diseases in developed countries. Hence, ameliorating the effects …
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Using the drug-protein interactome to identify anti-ageing compounds for humans (Research Article)
Gene expression-based drug repurposing to target aging (Research Article)
Aging is the largest risk factor for a variety of noncommunicable diseases. Model organism studies have shown that genetic and chemical …
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Gene expression-based drug repurposing to target aging (Research Article)